Rab7a-mTORC1 signaling-mediated cholesterol trafficking from the lysosome to mitochondria ameliorates hepatic lipotoxicity induced by aflatoxin B1 exposure.

Lin, Jin-Xian; Xu, Chi-Yu; Wu, Xin-Mou; Che, Lin; Li, Ting-Yu; Mo, Su-Min; Guo, Dong-Bei; Lin, Zhong-Ning; Lin, Yu-Chun

Lin, Jin-Xian; Xu, Chi-Yu; Wu, Xin-Mou; Che, Lin; Li, Ting-Yu; Mo, Su-Min; Guo, Dong-Bei; Lin, Zhong-Ning; Lin, Yu-Chun.

Afiliación

Lin JX; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, 361102, China.
Xu CY; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, 361102, China.
Wu XM; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, 361102, China.
Che L; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, 361102, China.
Li TY; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, 361102, China.
Mo SM; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, 361102, China.
Guo DB; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, 361102, China.
Lin ZN; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, 361102, China. Electronic address: linzhn@xmu.edu.cn.
Lin YC; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, 361102, China. Electronic address: linych@xmu.edu.cn.

Chemosphere ; 320: 138071, 2023 Apr.

Article en En | MEDLINE | ID: mdl-36754296

Asunto(s)

Aflatoxina B1; Hígado; Animales; Ratones; Aflatoxina B1/metabolismo; Colesterol/metabolismo; Hígado/metabolismo; Lisosomas/metabolismo; Mamíferos/metabolismo; Diana Mecanicista del Complejo 1 de la Rapamicina/metabolismo; Ratones Endogámicos C57BL; Mitocondrias/metabolismo; Proteínas de Unión a GTP rab7/metabolismo

Palabras clave

Aflatoxin B1 (AFB1); Cholesterol trafficking; Hepatic lipotoxicity; Lysosomes and mitochondria contact; Mammalian target of rapamycin complex 1 (mTORC1); Ras-associated protein 7a (Rab7a)

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Aflatoxina B1 / Hígado Límite: Animals Idioma: En Revista: Chemosphere Año: 2023 Tipo del documento: Article País de afiliación: China

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