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Estimating kidney function in patients with cancer: A narrative review.
Claudel, Sophie E; Gandhi, Malini; Patel, Ankit B; Verma, Ashish.
Afiliación
  • Claudel SE; Department of Internal Medicine, Boston Medical Center, Boston, Massachusetts, USA.
  • Gandhi M; Harvard Medical School, Boston, Massachusetts, USA.
  • Patel AB; Dana Farber Cancer Institute, Boston, Massachusetts, USA.
  • Verma A; Renal Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Acta Physiol (Oxf) ; 238(2): e13977, 2023 06.
Article en En | MEDLINE | ID: mdl-37057998
AIM: Accurate evaluation of glomerular filtration rate (GFR) is crucial in Oncology as drug eligibility and dosing depend on estimates of GFR. However, there are no clear guidelines on the optimal method of determining kidney function in patients with cancer. We aimed to summarize the evidence on estimation of kidney function in patients with cancer. METHODS: We searched PubMed for literature discussing the performance of GFR estimating equations in patients with malignancy to create a table of the evidence for creatinine- and cystatin c-based equations. We further reviewed novel estimation techniques such as panel eGFR, real-time measured GFR, and functional magnetic resonance imaging. RESULTS: The commonly used GFR estimating equations were derived from populations of patients without cancer. These equations may be less applicable in Oncology due to severe sarcopenia, inflammation, and other physiologic changes in patients with cancer. The Cockcroft-Gault equation currently dominates in clinical Oncology despite significant limitations and accumulating evidence for use of the CKD-EPICr formula. Additional considerations in the practice of Oncology include a recently developed equation (CamGFRv2, also called the Janowitz formula) and the use of cystatin c-based equations to overcome some of the barriers to accurate GFR estimation based on creatinine alone. CONCLUSION: Overall, we suggest using the CKD-EPI equations (either cystatin c or creatinine-based) among patients with cancer in routine clinical practice and measured GFR for patients at a critical threshold for treatment decisions.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Insuficiencia Renal Crónica / Neoplasias Tipo de estudio: Guideline / Prognostic_studies Límite: Humans Idioma: En Revista: Acta Physiol (Oxf) Asunto de la revista: FISIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Insuficiencia Renal Crónica / Neoplasias Tipo de estudio: Guideline / Prognostic_studies Límite: Humans Idioma: En Revista: Acta Physiol (Oxf) Asunto de la revista: FISIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos