The Pathological Mechanism of Neuronal Autophagy-Lysosome Dysfunction After Ischemic Stroke.
Cell Mol Neurobiol
; 43(7): 3251-3263, 2023 Oct.
Article
en En
| MEDLINE
| ID: mdl-37382853
ABSTRACT
The abnormal initiation of autophagy flux in neurons after ischemic stroke caused dysfunction of autophagy-lysosome, which not only led to autophagy flux blockage, but also resulted in autophagic death of neurons. However, the pathological mechanism of neuronal autophagy-lysosome dysfunction did not form a unified viewpoint until now. In this review, taking the autophagy lysosomal dysfunction of neurons as a starting point, we summarized the molecular mechanisms that led to neuronal autophagy lysosomal dysfunction after ischemic stroke, which would provide theoretical basis for the clinical treatment of ischemic stroke.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Autofagia
/
Accidente Cerebrovascular Isquémico
/
Lisosomas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Cell Mol Neurobiol
Año:
2023
Tipo del documento:
Article
País de afiliación:
China