Modulation of SK Channels via Calcium Buffering Tunes Intrinsic Excitability of Parvalbumin Interneurons in Neuropathic Pain: A Computational and Experimental Investigation.

Ma, Xinyue; Miraucourt, Loïs S; Qiu, Haoyi; Sharif-Naeini, Reza; Khadra, Anmar

Ma, Xinyue; Miraucourt, Loïs S; Qiu, Haoyi; Sharif-Naeini, Reza; Khadra, Anmar.

Afiliación

Ma X; Integrated Program in Neuroscience, McGill University, Montreal, Quebec H3G 1Y6, Canada.
Miraucourt LS; Alan Edwards Center for Research on Pain, McGill University, Montreal, Quebec H3G 1Y6, Canada.
Qiu H; Alan Edwards Center for Research on Pain, McGill University, Montreal, Quebec H3G 1Y6, Canada.
Sharif-Naeini R; Department of Physiology, McGill University, Montreal, Quebec H3G 1Y6, Canada.
Khadra A; Alan Edwards Center for Research on Pain, McGill University, Montreal, Quebec H3G 1Y6, Canada.

J Neurosci ; 43(31): 5608-5622, 2023 08 02.

Article en En | MEDLINE | ID: mdl-37451982

Asunto(s)

Calcio; Neuralgia; Ratones; Masculino; Femenino; Animales; Parvalbúminas/metabolismo; Neuralgia/metabolismo; Interneuronas/fisiología; Asta Dorsal de la Médula Espinal/metabolismo

Palabras clave

Hodgkin-Huxley type model; bifurcation analysis; calcium buffering; calcium-activated potassium channel; neuropathic pain; spike frequency adaptation

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Calcio / Neuralgia Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Neurosci Año: 2023 Tipo del documento: Article País de afiliación: Canadá

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