Structural basis for membrane-proximal proteolysis of substrates by ADAM10.

Lipper, Colin H; Egan, Emily D; Gabriel, Khal-Hentz; Blacklow, Stephen C

Lipper, Colin H; Egan, Emily D; Gabriel, Khal-Hentz; Blacklow, Stephen C.

Afiliación

Lipper CH; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
Egan ED; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
Gabriel KH; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215, USA.
Blacklow SC; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215, USA. Electronic address: stephen_blacklow@hms.harvard.edu.

Cell ; 186(17): 3632-3641.e10, 2023 08 17.

Article en En | MEDLINE | ID: mdl-37516108

Asunto(s)

Proteína ADAM10; Animales; Proteína ADAM10/química; Proteína ADAM10/metabolismo; Proteína ADAM10/ultraestructura; Secretasas de la Proteína Precursora del Amiloide/química; Mamíferos/metabolismo; Proteolisis; Tetraspaninas/metabolismo; Humanos

Palabras clave

APP; Alzheimer's disease; Notch signaling; alpha-secretase; ectodomain shedding; metalloprotease; tetraspanin

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteína ADAM10 Límite: Animals / Humans Idioma: En Revista: Cell Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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