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Employing Pd nanoparticles decorated on halloysite nanotube/carbon composite for electrochemical aptasensing of HER2 in breast cancer patients.
Bi, Liangliang; Teng, Yue; Baghayeri, Mehdi; Bao, Jinlei.
Afiliación
  • Bi L; Department of Ultrasound Diagnosis, Affiliated Hospital of Hebei University, Baoding, 071000, Hebei, China.
  • Teng Y; Faculty of Medicine, Health and Life Science, Swansea University, SA2 8PP, Swansea, Wales, UK.
  • Baghayeri M; Department of Chemistry, Faculty of Science, Hakim Sabzevari University, PO. Box 397, Sabzevar, Iran. Electronic address: m.baghayeri@hsu.ac.ir.
  • Bao J; College of Nursing, Shandong Xiehe University, Jinan, Shandong, China.
Environ Res ; 237(Pt 2): 117030, 2023 Nov 15.
Article en En | MEDLINE | ID: mdl-37659641
An effective biosensing platform is described based on halloysite nanotube/carbon composite decorated with Pd nanoparticles (HNT/C@Pd NPs). A novel electrochemical aptasensor was designed using the proposed nano-platform to determine human epidermal growth factor receptor 2 (HER2), a breast cancer biomarker. Inherently, aptasensing interfaces provide high sensitivity and selectivity for tumor markers owing to the high specific surface area of HNT/C and good conductivity stems from deposition of Pd NPs into HNT/C composite. With a correlation coefficient of 0.996, the electrochemical aptasensor demonstrated a wide linear range from 0.03 ng/mL to 9 ng/mL. The limit of detection (LOD) of the established assay was 8 pg/mL based on S/N = 3 method. Further, the designed biosensor demonstrated acceptable selectivity, good reproducibility, and high stability. The applicability of the impedimetric sensor in human serum samples was also examined and compared to enzyme-linked immunosorbent assay (ELISA) assay (p-value >0.05). Based on the results, it was found that the proposed methodology can be used in quantification of breast cancer markers for early diagnosis and treatment.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Screening_studies Idioma: En Revista: Environ Res Año: 2023 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Screening_studies Idioma: En Revista: Environ Res Año: 2023 Tipo del documento: Article País de afiliación: China