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Early-childhood linear growth faltering in low- and middle-income countries.
Benjamin-Chung, Jade; Mertens, Andrew; Colford, John M; Hubbard, Alan E; van der Laan, Mark J; Coyle, Jeremy; Sofrygin, Oleg; Cai, Wilson; Nguyen, Anna; Pokpongkiat, Nolan N; Djajadi, Stephanie; Seth, Anmol; Jilek, Wendy; Jung, Esther; Chung, Esther O; Rosete, Sonali; Hejazi, Nima; Malenica, Ivana; Li, Haodong; Hafen, Ryan; Subramoney, Vishak; Häggström, Jonas; Norman, Thea; Brown, Kenneth H; Christian, Parul; Arnold, Benjamin F.
Afiliación
  • Benjamin-Chung J; Department of Epidemiology & Population Health, Stanford University, Stanford, CA, USA. jadebc@stanford.edu.
  • Mertens A; Division of Epidemiology & Biostatistics, University of California, Berkeley, Berkeley, CA, USA. jadebc@stanford.edu.
  • Colford JM; Chan Zuckerberg Biohub, San Francisco, CA, USA. jadebc@stanford.edu.
  • Hubbard AE; Division of Epidemiology & Biostatistics, University of California, Berkeley, Berkeley, CA, USA.
  • van der Laan MJ; Division of Epidemiology & Biostatistics, University of California, Berkeley, Berkeley, CA, USA.
  • Coyle J; Division of Epidemiology & Biostatistics, University of California, Berkeley, Berkeley, CA, USA.
  • Sofrygin O; Division of Epidemiology & Biostatistics, University of California, Berkeley, Berkeley, CA, USA.
  • Cai W; Division of Epidemiology & Biostatistics, University of California, Berkeley, Berkeley, CA, USA.
  • Nguyen A; Division of Epidemiology & Biostatistics, University of California, Berkeley, Berkeley, CA, USA.
  • Pokpongkiat NN; Division of Epidemiology & Biostatistics, University of California, Berkeley, Berkeley, CA, USA.
  • Djajadi S; Department of Epidemiology & Population Health, Stanford University, Stanford, CA, USA.
  • Seth A; Division of Epidemiology & Biostatistics, University of California, Berkeley, Berkeley, CA, USA.
  • Jilek W; Division of Epidemiology & Biostatistics, University of California, Berkeley, Berkeley, CA, USA.
  • Jung E; Division of Epidemiology & Biostatistics, University of California, Berkeley, Berkeley, CA, USA.
  • Chung EO; Division of Epidemiology & Biostatistics, University of California, Berkeley, Berkeley, CA, USA.
  • Rosete S; Division of Epidemiology & Biostatistics, University of California, Berkeley, Berkeley, CA, USA.
  • Hejazi N; Division of Epidemiology & Biostatistics, University of California, Berkeley, Berkeley, CA, USA.
  • Malenica I; Division of Epidemiology & Biostatistics, University of California, Berkeley, Berkeley, CA, USA.
  • Li H; Division of Epidemiology & Biostatistics, University of California, Berkeley, Berkeley, CA, USA.
  • Hafen R; Division of Epidemiology & Biostatistics, University of California, Berkeley, Berkeley, CA, USA.
  • Subramoney V; Division of Epidemiology & Biostatistics, University of California, Berkeley, Berkeley, CA, USA.
  • Häggström J; Division of Epidemiology & Biostatistics, University of California, Berkeley, Berkeley, CA, USA.
  • Norman T; Hafen Consulting, LLC, West Richland, WA, USA.
  • Brown KH; DVPL Tech, Dubai, United Arab Emirates.
  • Christian P; Cytel Inc., Waltham, MA, USA.
  • Arnold BF; Quantitative Sciences, Bill & Melinda Gates Foundation, Seattle, WA, USA.
Nature ; 621(7979): 550-557, 2023 Sep.
Article en En | MEDLINE | ID: mdl-37704719
Globally, 149 million children under 5 years of age are estimated to be stunted (length more than 2 standard deviations below international growth standards)1,2. Stunting, a form of linear growth faltering, increases the risk of illness, impaired cognitive development and mortality. Global stunting estimates rely on cross-sectional surveys, which cannot provide direct information about the timing of onset or persistence of growth faltering-a key consideration for defining critical windows to deliver preventive interventions. Here we completed a pooled analysis of longitudinal studies in low- and middle-income countries (n = 32 cohorts, 52,640 children, ages 0-24 months), allowing us to identify the typical age of onset of linear growth faltering and to investigate recurrent faltering in early life. The highest incidence of stunting onset occurred from birth to the age of 3 months, with substantially higher stunting at birth in South Asia. From 0 to 15 months, stunting reversal was rare; children who reversed their stunting status frequently relapsed, and relapse rates were substantially higher among children born stunted. Early onset and low reversal rates suggest that improving children's linear growth will require life course interventions for women of childbearing age and a greater emphasis on interventions for children under 6 months of age.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Países en Desarrollo / Trastornos del Crecimiento Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Child, preschool / Female / Humans / Infant / Newborn País/Región como asunto: Asia Idioma: En Revista: Nature Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Países en Desarrollo / Trastornos del Crecimiento Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Child, preschool / Female / Humans / Infant / Newborn País/Región como asunto: Asia Idioma: En Revista: Nature Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos