Your browser doesn't support javascript.
loading
Shared and distinct structural brain networks related to childhood maltreatment and social support: connectome-based predictive modeling.
Winter, Alexandra; Gruber, Marius; Thiel, Katharina; Flinkenflügel, Kira; Meinert, Susanne; Goltermann, Janik; Winter, Nils R; Borgers, Tiana; Stein, Frederike; Jansen, Andreas; Brosch, Katharina; Wroblewski, Adrian; Thomas-Odenthal, Florian; Usemann, Paula; Straube, Benjamin; Alexander, Nina; Jamalabadi, Hamidreza; Nenadic, Igor; Bonnekoh, Linda M; Dohm, Katharina; Leehr, Elisabeth J; Opel, Nils; Grotegerd, Dominik; Hahn, Tim; van den Heuvel, Martijn P; Kircher, Tilo; Repple, Jonathan; Dannlowski, Udo.
Afiliación
  • Winter A; Institute for Translational Psychiatry, University of Münster, Münster, Germany.
  • Gruber M; Institute for Translational Psychiatry, University of Münster, Münster, Germany.
  • Thiel K; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Goethe University, Frankfurt, Germany.
  • Flinkenflügel K; Institute for Translational Psychiatry, University of Münster, Münster, Germany.
  • Meinert S; Institute for Translational Psychiatry, University of Münster, Münster, Germany.
  • Goltermann J; Institute for Translational Psychiatry, University of Münster, Münster, Germany.
  • Winter NR; Institute for Translational Neuroscience, University of Münster, Münster, Germany.
  • Borgers T; Institute for Translational Psychiatry, University of Münster, Münster, Germany.
  • Stein F; Institute for Translational Psychiatry, University of Münster, Münster, Germany.
  • Jansen A; Institute for Translational Psychiatry, University of Münster, Münster, Germany.
  • Brosch K; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
  • Wroblewski A; Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus Liebig University Giessen, Giessen, Germany.
  • Thomas-Odenthal F; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
  • Usemann P; Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus Liebig University Giessen, Giessen, Germany.
  • Straube B; Core-Facility Brainimaging, Faculty of Medicine, University of Marburg, Marburg, Germany.
  • Alexander N; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
  • Jamalabadi H; Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus Liebig University Giessen, Giessen, Germany.
  • Nenadic I; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
  • Bonnekoh LM; Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus Liebig University Giessen, Giessen, Germany.
  • Dohm K; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
  • Leehr EJ; Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus Liebig University Giessen, Giessen, Germany.
  • Opel N; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
  • Grotegerd D; Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus Liebig University Giessen, Giessen, Germany.
  • Hahn T; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
  • van den Heuvel MP; Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus Liebig University Giessen, Giessen, Germany.
  • Kircher T; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
  • Repple J; Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus Liebig University Giessen, Giessen, Germany.
  • Dannlowski U; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Mol Psychiatry ; 28(11): 4613-4621, 2023 Nov.
Article en En | MEDLINE | ID: mdl-37714950
Childhood maltreatment (CM) has been associated with changes in structural brain connectivity even in the absence of mental illness. Social support, an important protective factor in the presence of childhood maltreatment, has been positively linked to white matter integrity. However, the shared effects of current social support and CM and their association with structural connectivity remain to be investigated. They might shed new light on the neurobiological basis of the protective mechanism of social support. Using connectome-based predictive modeling (CPM), we analyzed structural connectomes of N = 904 healthy adults derived from diffusion-weighted imaging. CPM predicts phenotypes from structural connectivity through a cross-validation scheme. Distinct and shared networks of white matter tracts predicting childhood trauma questionnaire scores and the social support questionnaire were identified. Additional analyses were applied to assess the stability of the results. CM and social support were predicted significantly from structural connectome data (all rs ≥ 0.119, all ps ≤ 0.016). Edges predicting CM and social support were inversely correlated, i.e., positively correlated with CM and negatively with social support, and vice versa, with a focus on frontal and temporal regions including the insula and superior temporal lobe. CPM reveals the predictive value of the structural connectome for CM and current social support. Both constructs are inversely associated with connectivity strength in several brain tracts. While this underlines the interconnectedness of these experiences, it suggests social support acts as a protective factor following adverse childhood experiences, compensating for brain network alterations. Future longitudinal studies should focus on putative moderating mechanisms buffering these adverse experiences.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pruebas Psicológicas / Maltrato a los Niños / Autoinforme / Conectoma / Sustancia Blanca Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Child / Humans Idioma: En Revista: Mol Psychiatry Asunto de la revista: BIOLOGIA MOLECULAR / PSIQUIATRIA Año: 2023 Tipo del documento: Article País de afiliación: Alemania

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pruebas Psicológicas / Maltrato a los Niños / Autoinforme / Conectoma / Sustancia Blanca Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Child / Humans Idioma: En Revista: Mol Psychiatry Asunto de la revista: BIOLOGIA MOLECULAR / PSIQUIATRIA Año: 2023 Tipo del documento: Article País de afiliación: Alemania