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Gut microbiome association with brain imaging markers, APOE genotype, calcium and vegetable intakes, and obesity in healthy aging adults.
Hammond, Tyler C; Green, Stefan J; Jacobs, Yael; Chlipala, George E; Xing, Xin; Heil, Sally; Chen, Anna; Aware, Chetan; Flemister, Abeoseh; Stromberg, Arnold; Balchandani, Priti; Lin, Ai-Ling.
Afiliación
  • Hammond TC; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, United States.
  • Green SJ; Department of Neuroscience, University of Kentucky, Lexington, KY, United States.
  • Jacobs Y; Genomics and Microbiome Core Facility, Rush University, Chicago, IL, United States.
  • Chlipala GE; BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
  • Xing X; Research Informatics Core, University of Illinois Chicago, Chicago, IL, United States.
  • Heil S; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, United States.
  • Chen A; Department of Computer Science, University of Kentucky, Lexington, KY, United States.
  • Aware C; Roy Blunt NextGen Precision Health, University of Missouri, Columbia, MO, United States.
  • Flemister A; Department of Radiology, University of Missouri, Columbia, MO, United States.
  • Stromberg A; School of Medicine, University of Missouri, Columbia, MO, United States.
  • Balchandani P; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, United States.
  • Lin AL; Roy Blunt NextGen Precision Health, University of Missouri, Columbia, MO, United States.
Front Aging Neurosci ; 15: 1227203, 2023.
Article en En | MEDLINE | ID: mdl-37736325
Introduction: Advanced age is a significant factor in changes to brain physiology and cognitive functions. Recent research has highlighted the critical role of the gut microbiome in modulating brain functions during aging, which can be influenced by various factors such as apolipoprotein E (APOE) genetic variance, body mass index (BMI), diabetes, and dietary intake. However, the associations between the gut microbiome and these factors, as well as brain structural, vascular, and metabolic imaging markers, have not been well explored. Methods: We recruited 30 community dwelling older adults between age 55-85 in Kentucky. We collected the medical history from the electronic health record as well as the Dietary Screener Questionnaire. We performed APOE genotyping with an oral swab, gut microbiome analysis using metagenomics sequencing, and brain structural, vascular, and metabolic imaging using MRI. Results: Individuals with APOE e2 and APOE e4 genotypes had distinct microbiota composition, and higher level of pro-inflammatory microbiota were associated higher BMI and diabetes. In contrast, calcium- and vegetable-rich diets were associated with microbiota that produced short chain fatty acids leading to an anti-inflammatory state. We also found that important gut microbial butyrate producers were correlated with the volume of the thalamus and corpus callosum, which are regions of the brain responsible for relaying and processing information. Additionally, putative proinflammatory species were negatively correlated with GABA production, an inhibitory neurotransmitter. Furthermore, we observed that the relative abundance of bacteria from the family Eggerthellaceae, equol producers, was correlated with white matter integrity in tracts connecting the brain regions related to language, memory, and learning. Discussion: These findings highlight the importance of gut microbiome association with brain health in aging population and could have important implications aimed at optimizing healthy brain aging through precision prebiotic, probiotic or dietary interventions.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Front Aging Neurosci Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Front Aging Neurosci Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos