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Association of fractal dimension and other retinal vascular network parameters with cognitive performance and neuroimaging biomarkers: The Multi-Ethnic Study of Atherosclerosis (MESA).
Ong, Sally S; Peavey, Jeremy J; Hiatt, Kevin D; Whitlow, Christopher T; Sappington, Rebecca M; Thompson, Atalie C; Lockhart, Samuel N; Chen, Haiying; Craft, Suzanne; Rapp, Stephen R; Fitzpatrick, Annette L; Heckbert, Susan R; Luchsinger, José A; Klein, Barbara E K; Meuer, Stacy M; Cotch, Mary Frances; Wong, Tien Y; Hughes, Timothy M.
Afiliación
  • Ong SS; Department of Ophthalmology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
  • Peavey JJ; Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
  • Hiatt KD; Department of Radiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
  • Whitlow CT; Department of Radiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
  • Sappington RM; Department of Ophthalmology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
  • Thompson AC; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
  • Lockhart SN; Department of Ophthalmology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
  • Chen H; Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
  • Craft S; Department of Psychiatry and Behavioral Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
  • Rapp SR; Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
  • Fitzpatrick AL; Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
  • Heckbert SR; Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA.
  • Luchsinger JA; Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA.
  • Klein BEK; Departments of Medicine and Epidemiology, Columbia University Irving Medical Center, New York, New York, USA.
  • Meuer SM; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.
  • Cotch MF; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.
  • Wong TY; National Eye Institute, National Institute of Health, Bethesda, Maryland, USA.
  • Hughes TM; Singapore Eye Research Institute, Singapore National Eye Center, Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore.
Alzheimers Dement ; 20(2): 941-953, 2024 Feb.
Article en En | MEDLINE | ID: mdl-37828734
ABSTRACT

INTRODUCTION:

Retinal vascular network changes may reflect the integrity of the cerebral microcirculation, and may be associated with cognitive impairment.

METHODS:

Associations of retinal vascular measures with cognitive function and MRI biomarkers were examined amongst Multi-Ethnic Study of Atherosclerosis (MESA) participants in North Carolina who had gradable retinal photographs at Exams 2 (2002 to 2004, n = 313) and 5 (2010 to 2012, n = 306), and detailed cognitive testing and MRI at Exam 6 (2016 to 2018).

RESULTS:

After adjustment for covariates and multiple comparisons, greater arteriolar fractal dimension (FD) at Exam 2 was associated with less isotropic free water of gray matter regions (ß = -0.0005, SE = 0.0024, p = 0.01) at Exam 6, while greater arteriolar FD at Exam 5 was associated with greater gray matter cortical volume (in mm3 , ß = 5458, SE = 20.17, p = 0.04) at Exam 6.

CONCLUSION:

Greater arteriolar FD, reflecting greater complexity of the branching pattern of the retinal arteries, is associated with MRI biomarkers indicative of less neuroinflammation and neurodegeneration.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fractales / Aterosclerosis Límite: Humans Idioma: En Revista: Alzheimers Dement Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fractales / Aterosclerosis Límite: Humans Idioma: En Revista: Alzheimers Dement Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos