Protein Plasma Levels of the IGF Signalling System Are Altered in Major Depressive Disorder.
Int J Mol Sci
; 24(20)2023 Oct 17.
Article
en En
| MEDLINE
| ID: mdl-37894932
ABSTRACT
The Insulin-like growth factor 2 (IGF-2) has been recently proven to alleviate depressive-like behaviors in both rats and mice models. However, its potential role as a peripheral biomarker has not been evaluated in depression. To do this, we measured plasma IGF-2 and other members of the IGF family such as Binding Proteins (IGFBP-1, IGFBP-3, IGFBP-5 and IGFBP-7) in a depressed group of patients (n = 51) and in a healthy control group (n = 48). In some of these patients (n = 15), we measured these proteins after a period (19 ± 6 days) of treatment with antidepressants. The Hamilton Depressive Rating Scale (HDRS) and the Self-Assessment Anhedonia Scale (SAAS) were used to measure depression severity and anhedonia, respectively. The general cognition state was assessed by the Mini-Mental State Examination (MMSE) test and memory with the Free and Cued Selective Reminding Test (FCSRT). The levels of both IGF-2 and IGFBP-7 were found to be significantly increased in the depressed group; however, only IGF-2 remained significantly elevated after correction by age and sex. On the other hand, the levels of IGF-2, IGFBP-3 and IGFBP-5 were significantly decreased after treatment, whereas only IGFBP-7 was significantly increased. Therefore, peripheral changes in the IGF family and their response to antidepressants might represent alterations at the brain level in depression.
Palabras clave
Free and Cued Selective Remaining Test (FCSRT); Hamilton Depression Rating Scale (HDRS); Insulin-like growth factor 2 (IGF-2); Insulin-like growth factor binding protein 1 (IGFBP-1); Insulin-like growth factor binding protein 3 (IGFBP-3); Insulin-like growth factor binding protein 5 (IGFBP-5); Insulin-like growth factor binding protein 7 (IGFBP-7); Mini-Mental State Examination (MMSE); Self-Assessment Anhedonia Scale (SAAS); depression
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Factor II del Crecimiento Similar a la Insulina
/
Trastorno Depresivo Mayor
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Int J Mol Sci
Año:
2023
Tipo del documento:
Article
País de afiliación:
España