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The combination of manogepix and itraconazole is synergistic and inhibits the growth of Madurella mycetomatis in vitro but not in vivo.
Konings, Mickey; Eadie, Kimberly; Strepis, Nikolaos; Nyuykonge, Bertrand; Fahal, Ahmed H; Verbon, Annelies; van de Sande, Wendy W J.
Afiliación
  • Konings M; Department of Medical Microbiology and Infectious Diseases, ErasmusMC University Medical Center Rotterdam, Dr. Molewaterplein 40, 3015GD, Rotterdam, The Netherlands.
  • Eadie K; Department of Medical Microbiology and Infectious Diseases, ErasmusMC University Medical Center Rotterdam, Dr. Molewaterplein 40, 3015GD, Rotterdam, The Netherlands.
  • Strepis N; Department of Medical Microbiology and Infectious Diseases, ErasmusMC University Medical Center Rotterdam, Dr. Molewaterplein 40, 3015GD, Rotterdam, The Netherlands.
  • Nyuykonge B; Department of Medical Microbiology and Infectious Diseases, ErasmusMC University Medical Center Rotterdam, Dr. Molewaterplein 40, 3015GD, Rotterdam, The Netherlands.
  • Fahal AH; Mycetoma Research Center, University of Khartoum, Khartoum, Sudan.
  • Verbon A; Department of Medical Microbiology and Infectious Diseases, ErasmusMC University Medical Center Rotterdam, Dr. Molewaterplein 40, 3015GD, Rotterdam, The Netherlands.
  • van de Sande WWJ; Department of Internal Medicine, UMC Utrecht, Utrecht, The Netherlands.
Med Mycol ; 61(11)2023 Nov 06.
Article en En | MEDLINE | ID: mdl-37960934
Treatment of Madurella mycetomatis-caused mycetoma consists of extensive exposure to antifungals and surgery. To improve therapy, we evaluated manogepix, a novel antifungal agent, as a therapeutic option against M. mycetomatis. Our findings suggest limited therapeutic potential for manogepix.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Madurella / Micetoma Límite: Animals Idioma: En Revista: Med Mycol Asunto de la revista: MEDICINA VETERINARIA / MICROBIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Países Bajos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Madurella / Micetoma Límite: Animals Idioma: En Revista: Med Mycol Asunto de la revista: MEDICINA VETERINARIA / MICROBIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Países Bajos