Percutaneous ethanol injection in thyroid nodular pathology and metastatic cervical adenopathies: A systematic review, meta-analysis and economic evaluation.
Endocrinol Diabetes Nutr (Engl Ed)
; 70(9): 572-583, 2023 Nov.
Article
en En
| MEDLINE
| ID: mdl-37996202
ABSTRACT
BACKGROUND:
Percutaneous ethanol injection (PEI) has been shown to be a valuable treatment for thyroid nodular pathology and metastatic cervical adenopathies.OBJECTIVE:
To evaluate the effectiveness, safety, and cost-effectiveness of PEI in thyroid nodular pathology and metastatic cervical adenopathies.METHODS:
A systematic review (SR) using meta-analysis was conducted on the effectiveness and safety of PEI. A SR on cost-effectiveness was also performed. The SRs were conducted according to the methodology developed by the Cochrane Collaboration with reporting in accordance with the PRISMA statement. A cost-minimization analysis was carried out using a decision tree model. Assuming equal effectiveness between two minimally invasive techniques (PEI and radiofrequency ablation (RFA)), the model compared the costs of the alternatives with a horizon of six months and from the perspective of the Spanish National Health System.RESULTS:
The search identified three RCTs (n=157) that evaluated PEI versus RFA in patients diagnosed with benign thyroid nodules ninety-six patients with predominantly cystic nodules and sixty-one patients with solid nodules. No evidence was found on other techniques or thyroid nodular pathology. No statistically significant differences were observed between PEI and RFA in volume reduction (%), symptom score, cosmetic score, therapeutic success and major complications. No economic evaluations were identified. The cost-minimization analysis estimated the cost per patient of the PEI procedure at 326 compared to 4781 for RFA, which means an incremental difference of -4455.CONCLUSIONS:
There are no differences between PEI and RFA regarding their safety and effectiveness, but the economic evaluation determined that the former option is cheaper.Palabras clave
Ablación por radiofrecuencia; Cost-effectiveness; Coste-efectividad; Efectividad; Effectiveness; España; Inyección percutánea de etanol; Meta-analysis; Metanálisis; Patología nodular tiroidea; Percutaneous ethanol injection; Radiofrequency ablation; Safety; Seguridad; Spain; Thyroid nodular pathology
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Nódulo Tiroideo
/
Ablación por Catéter
/
Linfadenopatía
Tipo de estudio:
Systematic_reviews
Límite:
Humans
Idioma:
En
Revista:
Endocrinol Diabetes Nutr (Engl Ed)
Año:
2023
Tipo del documento:
Article