Negative Impact of TET2 Mutations on Long-Term Survival After Transcatheter Aortic Valve Replacement.
JACC Basic Transl Sci
; 8(11): 1424-1435, 2023 Nov.
Article
en En
| MEDLINE
| ID: mdl-38093739
ABSTRACT
Clonal hematopoiesis of indeterminate potential (CHIP) is considered as being a novel age-related risk factor for cardiovascular diseases. By capture-sequencing of a 67-gene panel, we established a large spectrum of CHIP in 258 patients with aortic valve stenosis undergoing transcatheter aortic valve replacement (TAVR) and assessed their association with long-term survival after TAVR. One or several CHIP variants in 35 genes were identified in 68% of the cohort, DNMT3A and TET2 being the 2 most frequently mutated genes. Patients carrying a TET2-CHIP-driver variant with low variant allele frequency (2%-10%) had a significant decrease in overall survival 5 years after TAVR.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
JACC Basic Transl Sci
Año:
2023
Tipo del documento:
Article
País de afiliación:
Francia