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Long-Term Exposure to Low Concentrations of Ambient Benzene and Mortality in a National English Cohort.
Wang, Jianing; Ma, Yudiyang; Tang, Linxi; Li, Dankang; Xie, Junqing; Sun, Yu; Tian, Yaohua.
Afiliación
  • Wang J; Ministry of Education Key Laboratory of Environment and Health, State Key Laboratory of Environmental Health (Incubating).
  • Ma Y; Department of Maternal and Child Health, School of Public Health, and.
  • Tang L; Ministry of Education Key Laboratory of Environment and Health, State Key Laboratory of Environmental Health (Incubating).
  • Li D; Department of Maternal and Child Health, School of Public Health, and.
  • Xie J; Ministry of Education Key Laboratory of Environment and Health, State Key Laboratory of Environmental Health (Incubating).
  • Sun Y; Department of Maternal and Child Health, School of Public Health, and.
  • Tian Y; Ministry of Education Key Laboratory of Environment and Health, State Key Laboratory of Environmental Health (Incubating).
Am J Respir Crit Care Med ; 209(8): 987-994, 2024 04 15.
Article en En | MEDLINE | ID: mdl-38128545
ABSTRACT

Background:

Benzene affects human health through environmental exposure in addition to occupational contact. However, few studies have examined the associations between long-term exposure to low concentrations of ambient benzene and mortality risks in nonoccupational settings.

Methods:

This prospective cohort study consists of 393,042 participants without stroke, myocardial infarction, or cancer at baseline from the UK Biobank. Annual average concentrations of benzene for each year during follow-up were measured using air dispersion models. The main outcomes were all-cause mortality and mortality from specific causes. Cox proportional-hazards models with time-varying exposure measurements were used to estimate the hazard ratios and 95% confidence intervals (CIs) for mortality risks. Restricted cubic spline models were used to estimate exposure-response relationships.Measurements and Main

Results:

With each interquartile range increase in the average annual concentration of benzene, the adjusted hazard ratios of mortality risk from all causes, cardiovascular disease, cancer, and respiratory disease were 1.26 (95% CI, 1.24-1.27), 1.24 (95% CI, 1.21-1.28), 1.27 (95% CI, 1.25-1.29), and 1.25 (95% CI, 1.20-1.30), respectively. The monotonically increasing exposure-response curves showed no threshold and plateau within the observed concentration range. Furthermore, the effect of benzene exposure on mortality persisted across different subgroups and was somewhat stronger in younger and White people (P for interaction < 0.05).

Conclusions:

Long-term exposure to low concentrations of ambient benzene significantly increases mortality risk in the general population. Ambient benzene represents a potential threat to public health, and further investigations are needed to support timely pollution regulation and health protection.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Contaminantes Atmosféricos / Contaminación del Aire / Infarto del Miocardio / Neoplasias Límite: Humans Idioma: En Revista: Am J Respir Crit Care Med Asunto de la revista: TERAPIA INTENSIVA Año: 2024 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Contaminantes Atmosféricos / Contaminación del Aire / Infarto del Miocardio / Neoplasias Límite: Humans Idioma: En Revista: Am J Respir Crit Care Med Asunto de la revista: TERAPIA INTENSIVA Año: 2024 Tipo del documento: Article