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Multilayer track-etched membrane-based electroosmotic pump for drug delivery.
Yang, Qian; Zhang, Zebo; Lin, Junshu; Zhu, Boyu; Yu, Rongying; Li, Xinru; Su, Bin; Zhao, Bo.
Afiliación
  • Yang Q; School of Micro-Nano Electronics, Zhejiang University, Hangzhou, P. R. China.
  • Zhang Z; Internet of Things Research Center, Advanced Institute of Information Technology, Peking University, Hangzhou, P. R. China.
  • Lin J; Internet of Things Research Center, Advanced Institute of Information Technology, Peking University, Hangzhou, P. R. China.
  • Zhu B; Internet of Things Research Center, Advanced Institute of Information Technology, Peking University, Hangzhou, P. R. China.
  • Yu R; Key Laboratory of Excited-State Materials of Zhejiang Province, Department of Chemistry, Zhejiang University, Hangzhou, P. R. China.
  • Li X; Internet of Things Research Center, Advanced Institute of Information Technology, Peking University, Hangzhou, P. R. China.
  • Su B; Key Laboratory of Excited-State Materials of Zhejiang Province, Department of Chemistry, Zhejiang University, Hangzhou, P. R. China.
  • Zhao B; Key Laboratory of Excited-State Materials of Zhejiang Province, Department of Chemistry, Zhejiang University, Hangzhou, P. R. China.
Electrophoresis ; 45(5-6): 433-441, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38161243
ABSTRACT
Herein, we report an electroosmotic pump (EOP) based on a multilayer track-etched polycarbonate (PC) membrane. A remarkable increase of maximum backpressure (198.2-2400 mmH2 O) of a fundamental pump unit was obtained at 0.8 mA, when the number of PC membranes was increased from 1 to 10. Meanwhile, the corresponding flow rate was increased from 80.3 to 111.7 µL/min. Furthermore, multiple pump units were assembled in series to obtain a multistage EOP. For a three-stage EOP (EOP-3), the operating voltage and power can be decreased significantly by 52%-72% under different driving currents, with a minimum power of 26.7 µW. Thus, EOP-3 can run stably over 35 h at a pulse current of 0.1 mA without the generation of gas bubbles. The pump was further integrated into a miniature device, which was successfully used to decrease the blood glucose level of diabetic rats by subcutaneous delivery of fast-acting insulin. This work brings a facile and efficient strategy to enhance the backpressure and lower the operating voltage and power of EOPs, which may find promising applications in drug delivery.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Diabetes Mellitus Experimental Límite: Animals Idioma: En Revista: Electrophoresis Año: 2024 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Diabetes Mellitus Experimental Límite: Animals Idioma: En Revista: Electrophoresis Año: 2024 Tipo del documento: Article