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Genetic analyses identify brain imaging-derived phenotypes associated with the risk of intracerebral hemorrhage.
Liu, Yi; Jia, Yiming; Sun, Hongyan; Sun, Lulu; Wang, Yinan; Xu, Qingyun; He, Yu; Chang, Xinyue; Guo, Daoxia; Shi, Mengyao; Chen, Guo-Chong; Zheng, Jin; Zhu, Zhengbao.
Afiliación
  • Liu Y; Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, 199 Renai Road, Industrial Park District, Suzhou Medical College of Soochow University, Suzhou, Jiangs
  • Jia Y; Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, 199 Renai Road, Industrial Park District, Suzhou Medical College of Soochow University, Suzhou, Jiangs
  • Sun H; Department of Medical Imaging, 11 Guangqian Road, Xiangcheng District, The Affiliated Guangji Hospital of Soochow University, Suzhou, China.
  • Sun L; Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, 199 Renai Road, Industrial Park District, Suzhou Medical College of Soochow University, Suzhou, Jiangs
  • Wang Y; Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, 199 Renai Road, Industrial Park District, Suzhou Medical College of Soochow University, Suzhou, Jiangs
  • Xu Q; Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, 199 Renai Road, Industrial Park District, Suzhou Medical College of Soochow University, Suzhou, Jiangs
  • He Y; Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, 199 Renai Road, Industrial Park District, Suzhou Medical College of Soochow University, Suzhou, Jiangs
  • Chang X; Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, 199 Renai Road, Industrial Park District, Suzhou Medical College of Soochow University, Suzhou, Jiangs
  • Guo D; School of Nursing, 333 Ganjiang East Road, Gusu District, Suzhou Medical College of Soochow University, Suzhou, China.
  • Shi M; Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, 199 Renai Road, Industrial Park District, Suzhou Medical College of Soochow University, Suzhou, Jiangs
  • Chen GC; Department of Nutrition and Food Hygiene, School of Public Health, 199 Renai Road, Industrial Park District, Suzhou Medical College of Soochow University, Suzhou, China.
  • Zheng J; Department of Neurology, Minhang Hospital, 170 Xinsong Road, Xinzhuang Town, Minhang District, Fudan University, Shanghai, China.
  • Zhu Z; Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, 199 Renai Road, Industrial Park District, Suzhou Medical College of Soochow University, Suzhou, Jiangs
Cereb Cortex ; 34(2)2024 01 31.
Article en En | MEDLINE | ID: mdl-38185989
ABSTRACT
Previous observational studies have reported associations between brain imaging-derived phenotypes (IDPs) and intracerebral hemorrhage (ICH), but the causality between them remains uncertain. We aimed to investigate the potential causal relationship between IDPs and ICH by a two-sample Mendelian randomization (MR) study. We selected genetic instruments for 363 IDPs from a genome-wide association study (GWASs) based on the UK Biobank (n = 33,224). Summary-level data on ICH was derived from a European-descent GWAS with 1,545 cases and 1,481 controls. Inverse variance weighted MR method was applied in the main analysis to investigate the associations between IDPs and ICH. Reverse MR analyses were performed for significant IDPs to examine the reverse causation for the identified associations. Among the 363 IDPs, isotropic or free water volume fraction (ISOVF) in the anterior limb of the left internal capsule was identified to be associated with the risk of ICH (OR per 1-SD increase, 4.62 [95% CI, 2.18-9.81], P = 6.63 × 10-5). In addition, the reverse MR analysis indicated that ICH had no effect on ISOVF in the anterior limb of the left internal capsule (beta, 0.010 [95% CI, -0.010-0.030], P = 0.33). MR-Egger regression analysis showed no directional pleiotropy for the association between ISOVF and ICH, and sensitivity analyses with different MR models further confirmed these findings. ISOVF in the anterior limb of the left internal capsule might be a potential causal mediator of ICH, which may provide predictive guidance for the prevention of ICH. Further studies are warranted to replicate our findings and clarify the underlying mechanisms.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Estudio de Asociación del Genoma Completo Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Cereb Cortex Asunto de la revista: CEREBRO Año: 2024 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Estudio de Asociación del Genoma Completo Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Cereb Cortex Asunto de la revista: CEREBRO Año: 2024 Tipo del documento: Article