Randomized Trial to Improve Body Composition and Micronutrient Status Among South African Children.
Am J Prev Med
; 66(6): 1078-1088, 2024 06.
Article
en En
| MEDLINE
| ID: mdl-38309672
ABSTRACT
INTRODUCTION:
Physical activity (PA) promotion combined with multimicronutrient supplementation (MMNS) among school-age children may reduce fat mass accrual and increase muscle mass through different mechanisms and so benefit child health. This study determined the efficacy of combined interventions on body composition among South African schoolchildren and determined if micronutrients mediate these effects. STUDYDESIGN:
Longitudinal cluster randomized controlled trial of children followed from 2019 to 2021. Statistical analyses carried from 2022 to 2023. SETTING/PARTICIPANTS:
A total of 1,304 children 6-12 years of age recruited from public schools in Gqeberha, South Africa. INTERVENTION Children were randomized by classes to either (a) a physical activity group (PA); (b) a MMNS group; (c) a physical activity + multimicronutrient supplementation group (PA + MMNS); and (d) a placebo control group. MAIN OUTCOMEMEASURES:
Trajectories of overall and truncal fat free mass (FFM) and fat mass (FM) estimates in modeled at 9 and 21 months using latent growth curve models (LGCM). Changes in micronutrient concentrations at 9 months from baseline.RESULTS:
An increased FFM trajectory was found among children in the MMNS arm at 9 months (Beta 0.16, 95% CI = 0.12, 0.31). The PA and MMNS arms both had positive indirect effects on this trajectory at 9 months (Beta 0.66, 95% CI = 0.44, 0.88 and Beta 0.32 95% CI = 0.1 0.5, respectively) and similarly at 21 months when mediated by zinc concentration changes. A reduced FM trajectory was found among children in the PA promotion arm at 9 months when using this collection point as the referent intercept. This arm was inversely associated with the FM trajectory at 9 months when mediated by zinc changes.CONCLUSIONS:
PA and MMNS promotion in school-based interventions directly contributed to reductions in FM and increased FFM among South African children and indirectly through changes in micronutrient status. TRIAL REGISTRATION ISRCTN, ISRCTN29534081. Registered on August 9, 2018 Institutional review board Ethikkommission Nordwest- und Zentralschweiz" (EKNZ, project number Req-2018-00608). Date of approval 2018.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Composición Corporal
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Ejercicio Físico
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Micronutrientes
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Suplementos Dietéticos
Tipo de estudio:
Clinical_trials
Límite:
Child
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Female
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Humans
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Male
País/Región como asunto:
Africa
Idioma:
En
Revista:
Am J Prev Med
Asunto de la revista:
SAUDE PUBLICA
Año:
2024
Tipo del documento:
Article