Schisandrin B ameliorates adjuvant-induced arthritis in rats via modulation of inflammatory mediators, oxidative stress, and HIF-1α/VEGF pathway.
J Pharm Pharmacol
; 76(6): 681-690, 2024 Jun 06.
Article
en En
| MEDLINE
| ID: mdl-38422325
ABSTRACT
OBJECTIVES:
Schisandrin B (Sch B) has been shown to possess anti-inflammatory and antioxidant properties, however, its antirheumatoid arthritis properties and potential mechanism remain unexplored. This study evaluated the potential of Sch B in adjuvant-induced arthritic (AIA) rats.METHODS:
AIA was induced by injecting 0.1 ml of CFA into the paw of rats and the animals were administered with Sch B (50 mg/kg) for 28 days. The effects of Sch B were evaluated using arthritis severity, serum levels of oxido-inflammatory, and metabolic index parameters. KEYFINDINGS:
Sch B eased arthritic symptoms by significantly reducing paw swelling and arthritic score and increased body weight gain. Moreover, Sch B alleviated the levels of oxido-inflammatory markers including interleukin-1 beta, interleukin-6, tumor necrosis factor alpha, nuclear factor kappa B, transforming growth factor ß1, inducible nitric oxide synthase and malonaldehyde, as well as increased the levels of superoxide dismutase, glutathione, and Nrf2. Sch B also remarkably restored the altered levels of triglyceride, aspartate aminotransferase, lactic acid, pyruvate, phosphoenolpyruvate carboxylase, glucose, hypoxia inducible factor-1 alpha, and vascular endothelial growth factor. In addition, Sch B markedly alleviated p65 expression in the treated AIA rats.CONCLUSION:
This study suggests that Sch B alleviated AIA by reducing oxidative stress, inflammation, and angiogenesis.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Compuestos Policíclicos
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Artritis Experimental
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Lignanos
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Estrés Oxidativo
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Mediadores de Inflamación
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Ciclooctanos
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Factor A de Crecimiento Endotelial Vascular
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Subunidad alfa del Factor 1 Inducible por Hipoxia
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Antiinflamatorios
Límite:
Animals
Idioma:
En
Revista:
J Pharm Pharmacol
Año:
2024
Tipo del documento:
Article
País de afiliación:
China