Determination of carbamazepine in fingerprints: a feasibility study to evaluate adherence in epilepsy patients.
Bioanalysis
; 16(9): 415-427, 2024.
Article
en En
| MEDLINE
| ID: mdl-38497729
ABSTRACT
Background:
Fingerprint drug concentrations can be used as a noninvasive and convenient alternative to evaluate adherence to pharmacotherapy.Methods:
Fingerprints were applied over glass slides, extracted and analyzed by ultra-high performance LC-MS/MS. The assay and drug adherence questionnaires were applied to 30 epilepsy patients.Results:
The assay had linearity in the range 0.05-10 ng fingerprint-1, with precision of 2.16-7.9% and accuracy of 95.0-102.8%. Carbamazepine (CBZ) levels in fingerprints were stable at 45°C for 15 days. Concentrations in patient samples were 0.06-9.28 ng fingerprint-1. A significant difference (p = 0.003) was found between CBZ concentrations in fingerprints between patient groups divided as low and medium/high adherence.Conclusion:
This method can potentially be applied to the identification of epilepsy patients with low adherence to CBZ pharmacotherapy.
[Box see text].
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Carbamazepina
/
Estudios de Factibilidad
/
Epilepsia
/
Espectrometría de Masas en Tándem
/
Cumplimiento de la Medicación
Límite:
Adult
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Bioanalysis
Año:
2024
Tipo del documento:
Article
País de afiliación:
Brasil