Marginal Zone Lymphoma Manifesting as Macrophage Activation Syndrome: A Case Report.
J Investig Med High Impact Case Rep
; 12: 23247096241244732, 2024.
Article
en En
| MEDLINE
| ID: mdl-38577998
ABSTRACT
Macrophage activation syndrome (MAS) is a form of secondary hemophagocytic lymphohistiocytosis (HLH) when it occurs in the context of rheumatologic disorders. HLH is a rare and potentially life-threatening syndrome characterized by excessive immune system activation. It is mainly seen in children and can be genetic based or related to infections, malignancies, rheumatologic disorders, or immunodeficiency syndromes. MAS can present with nonspecific symptoms, leading to a delay in diagnosis. This report describes a case of a 64-year-old female with marginal zone lymphoma and systemic lupus erythematosus who presented with a purpuric rash and acute kidney injury. She underwent a kidney biopsy and was diagnosed with MAS. This case highlights the importance of promptly recognizing MAS's symptoms and signs, allowing timely diagnosis and early therapeutic intervention. This potentially fatal condition tends to respond well to rapid treatment initiation with corticosteroids and to address the underlying condition.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Artritis Reumatoide
/
Linfoma de Células B de la Zona Marginal
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Linfohistiocitosis Hemofagocítica
/
Síndrome de Activación Macrofágica
Límite:
Female
/
Humans
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Middle aged
Idioma:
En
Revista:
J Investig Med High Impact Case Rep
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos