The preventive effect of Gastrodia elata Blume extract on vancomycin-induced acute kidney injury in rats.
Lab Anim Res
; 40(1): 14, 2024 Apr 08.
Article
en En
| MEDLINE
| ID: mdl-38589968
ABSTRACT
BACKGROUND:
Gastrodia elata Blume (GEB), a traditional medicinal herb, has been reported to have pharmacological effect including protection against liver, neuron and kidney toxicity. However, explanation of its underlying mechanisms remains a great challenge. This study investigated the protective effects of GEB extract on vancomycin (VAN)-induced nephrotoxicity in rats and underlying mechanisms with emphasis on the anti-oxidative stress, anti-inflammation and anti-apoptosis. The male Sprague-Dawley rats were randomly divided three groups control (CON) group, VAN group and GEB group with duration of 14 days.RESULTS:
The kidney weight and the serum levels of blood urea nitrogen and creatinine in the GEB group were lower than the VAN group. Histological analysis using hematoxylin & eosin and periodic acid Schiff staining revealed pathological changes of the VAN group. Immunohistochemical analysis revealed that the expression levels of N-acetyl-D-glucosaminidase, myeloperoxidase and tumor necrosis factor-alpha in the GEB group were decreased when compared with the VAN group. The number of terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling-positive cells, phosphohistone and malondialdehyde levels were lower in the GEB group than VAN group. The levels of total glutathione in the GEB group were higher than the VAN group.CONCLUSIONS:
The findings of this study suggested that GEB extract prevents VAN-induced renal tissue damage through anti-oxidation, anti-inflammation and anti-apoptosis.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
Lab Anim Res
Año:
2024
Tipo del documento:
Article