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Risk of depression in persons with Alzheimer's disease: A national cohort study.
Crump, Casey; Sieh, Weiva; Vickrey, Barbara G; Edwards, Alexis C; Sundquist, Jan; Sundquist, Kristina.
Afiliación
  • Crump C; Departments of Family and Community Medicine and of Epidemiology The University of Texas Health Science Center Houston Texas USA.
  • Sieh W; Department of Epidemiology The University of Texas M. D. Anderson Cancer Center Houston Texas USA.
  • Vickrey BG; Department of Neurology Icahn School of Medicine at Mount Sinai New York New York USA.
  • Edwards AC; Department of Psychiatry Virginia Commonwealth University Richmond Virginia USA.
  • Sundquist J; Department of Clinical Sciences Center for Primary Health Care Research Lund University Malmö Sweden.
  • Sundquist K; Department of Clinical Sciences Center for Primary Health Care Research Lund University Malmö Sweden.
Alzheimers Dement (Amst) ; 16(2): e12584, 2024.
Article en En | MEDLINE | ID: mdl-38623385
ABSTRACT

INTRODUCTION:

Depression is a risk factor and possible prodromal symptom of Alzheimer's disease (AD), but little is known about subsequent risk of developing depression in persons with AD.

METHODS:

National matched cohort study was conducted of all 129,410 persons diagnosed with AD and 390,088 with all-cause dementia during 1998-2017 in Sweden, and 3,900,880 age- and sex-matched controls without dementia, who had no prior depression. Cox regression was used to compute hazard ratios (HRs) for major depression through 2018.

RESULTS:

Cumulative incidence of major depression was 13% in persons with AD and 3% in controls. Adjusting for sociodemographic factors and comorbidities, risk of major depression was greater than two-fold higher in women with AD (HR, 2.21; 95% confidence interval [CI], 2.11-2.32) or men with AD (2.68; 2.52-2.85), compared with controls. Similar results were found for all-cause dementia.

DISCUSSION:

Persons diagnosed with AD or related dementias need close follow-up for timely detection and treatment of depression. Highlights In a large cohort, women and men with AD had >2-fold subsequent risk of depression.Risks were highest in the first year (>3-fold) but remained elevated ≥3 years later.Risk of depression was highest in persons aged ≥85 years at AD diagnosis.Persons with AD need close follow-up for detection and treatment of depression.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Alzheimers Dement (Amst) Año: 2024 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Alzheimers Dement (Amst) Año: 2024 Tipo del documento: Article