Potential therapeutic targets of fibrosis in inflammatory rheumatic diseases.
Best Pract Res Clin Rheumatol
; 38(2): 101945, 2024 05.
Article
en En
| MEDLINE
| ID: mdl-38627168
ABSTRACT
Fibrosis is commonly associated with chronic rheumatic diseases, and causes substantial morbidity and mortality. Treatment of fibrosis is extremely challenging but is badly needed, as approved antifibrotic therapies fibrosis do not halt its progression, which will be discussed with a focus on pulmonary fibrosis. Findings from recent studies indicate several therapeutic targets for treating fibrosis. Interleukin-11 is emerging as a fibrogenic cytokine whose activity can be blocked with neutralizing monoclonal antibodies. Fibroblast activation protein (FAP) is highly expressed by activated fibroblasts in inflammatory and fibrotic tissues. Targeting FAP with different modalities has been extensively explored as adjunct treatment for cancer, which can also apply to treating fibrosis in rheumatic diseases.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Enfermedades Reumáticas
Límite:
Humans
Idioma:
En
Revista:
Best Pract Res Clin Rheumatol
Asunto de la revista:
REUMATOLOGIA
Año:
2024
Tipo del documento:
Article