Deconstructing cancer with precision genome editing.
Biochem Soc Trans
; 52(2): 803-819, 2024 04 24.
Article
en En
| MEDLINE
| ID: mdl-38629716
ABSTRACT
Recent advances in genome editing technologies are allowing investigators to engineer and study cancer-associated mutations in their endogenous genetic contexts with high precision and efficiency. Of these, base editing and prime editing are quickly becoming gold-standards in the field due to their versatility and scalability. Here, we review the merits and limitations of these precision genome editing technologies, their application to modern cancer research, and speculate how these could be integrated to address future directions in the field.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Sistemas CRISPR-Cas
/
Edición Génica
/
Neoplasias
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Biochem Soc Trans
/
Biochem. Soc. Trans
/
Biochemical society transactions
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos