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Echocardiographic measures of the left heart and cerebrospinal fluid biomarkers of Alzheimer's disease pathology in cognitively intact adults: The CABLE study.
Hu, He-Ying; Hu, Hao; Jiang, Jing; Bi, Yan-Lin; Sun, Yan; Ou, Ya-Nan; Tan, Lan; Yu, Jin-Tai.
Afiliación
  • Hu HY; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, Shandong, China.
  • Hu H; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, Shandong, China.
  • Jiang J; Department of Cardiac Ultrasonography, Qingdao Municipal Hospital, Qingdao University, Qingdao, Shandong, China.
  • Bi YL; Department of Anesthesiology, Qingdao Municipal Hospital, Qingdao University, Qingdao, Shandong, China.
  • Sun Y; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, Shandong, China.
  • Ou YN; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, Shandong, China.
  • Tan L; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, Shandong, China.
  • Yu JT; Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China.
Alzheimers Dement ; 20(6): 3943-3957, 2024 06.
Article en En | MEDLINE | ID: mdl-38676443
ABSTRACT

INTRODUCTION:

This study delineated the interrelationships between subclinical alterations in the left heart, cerebrospinal fluid (CSF), Alzheimer's disease (AD) biomarkers, and cognition.

METHODS:

Multiple linear regressions were conducted in 1244 cognitively normal participants (mean age = 65.5; 43% female) who underwent echocardiography (left atrial [LA] and left ventricular [LV] morphologic or functional parameters) and CSF AD biomarkers measurements. Mediating effects of AD pathologies were examined. Differences in cardiac parameters across ATN categories were tested using analysis of variance (ANOVA) and logistic regressions.

RESULTS:

LA or LV enlargement (characterized by increased diameters and volumes) and LV hypertrophy (increased interventricular septal or posterior wall thickness and ventricular mass) were associated with higher CSF phosphorylated (p)-tau and total (t)-tau levels, and poorer cognition. Tau pathologies mediated the heart-cognition relationships. Cardiac parameters were higher in stage 2 and suspected non-Alzheimer's pathology groups than controls.

DISCUSSION:

These findings suggested close associations of subclinical cardiac changes with tau pathologies and cognition. HIGHLIGHTS Various subclinical alterations in the left heart related to poorer cognition. Subclinical cardiac changes related to tau pathologies in cognitively normal adults. Tau pathologies mediated the heart-cognition relationships. Subclinical cardiac changes related to the AD continuum, especially to stage 2. The accumulation of cardiac alterations magnified their damage to the brain.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ecocardiografía / Biomarcadores / Proteínas tau / Enfermedad de Alzheimer Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Alzheimers Dement Año: 2024 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ecocardiografía / Biomarcadores / Proteínas tau / Enfermedad de Alzheimer Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Alzheimers Dement Año: 2024 Tipo del documento: Article País de afiliación: China