The Role of Total-Body PET in Drug Development and Evaluation: Status and Outlook.
J Nucl Med
; 65(Suppl 1): 46S-53S, 2024 May 06.
Article
en En
| MEDLINE
| ID: mdl-38719239
ABSTRACT
Total-body PET, an emerging technique, enables high-quality simultaneous total-body dynamic PET acquisition and accurate kinetic analysis. It has the potential to facilitate the study of multiple tracers while minimizing radiation dose and improving tracer-specific imaging. This advancement holds promise for enhancing the development and clinical evaluation of drugs, particularly radiopharmaceuticals. Multiple clinical trials are using a total-body PET scanner to explore existing and innovative radiopharmaceuticals. However, challenges persist, along with the opportunities, with regard to the use of total-body PET in drug development and evaluation. Specifically, considerations relate to the role of total-body PET in clinical pharmacologic evaluations and its integration into the theranostic paradigm. In this review, state-of-the-art total-body PET and its potential roles in pharmaceutical research are explored.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Tomografía de Emisión de Positrones
/
Imagen de Cuerpo Entero
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Desarrollo de Medicamentos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Nucl Med
/
J. nucl. med
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Journal of nuclear medicine
Año:
2024
Tipo del documento:
Article