Targeting arrhythmogenic macrophages: lessons learned from arrhythmogenic cardiomyopathy.
J Clin Invest
; 134(10)2024 May 15.
Article
en En
| MEDLINE
| ID: mdl-38747296
ABSTRACT
Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiac condition characterized by cardiac remodeling and life-threatening ventricular arrhythmias. In this issue of the JCI, Chelko, Penna, and colleagues mechanistically addressed the intricate contribution of immune-mediated injury in ACM pathogenesis. Inhibition of nuclear factor κ-B (NF-κB) and infiltration of monocyte-derived macrophages expressing C-C motif chemokine receptor-2 (CCR2) alleviated the phenotypic ACM features (i.e., fibrofatty replacement, contractile dysfunction, and ventricular arrhythmias) in desmoglein 2-mutant (Dsg2mut/mut) mice. These findings pave the way for efficacious and targetable immune therapy for patients with ACM.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Desmogleína 2
/
Receptores CCR2
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Macrófagos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Clin Invest
Año:
2024
Tipo del documento:
Article