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Lipid and hemolysis parameters predicting acute chest syndrome in adulthood with sickle cell disease.
Feugray, Guillaume; Grall, Maximilien; Dumesnil, Cécile; Brunel, Valéry; Benhamou, Ygal; Quillard Muraine, Muriel; Billoir, Paul.
Afiliación
  • Feugray G; Department of General Biochemistry, Normandie Univ, UNIROUEN, INSERM U1096 EnVI, CHU Rouen, Rouen, F-76000, France. guillaume.feugray@chu-rouen.fr.
  • Grall M; Service de Biochimie, Centre hospitalier Universitaire Charles Nicolle, 1 rue de Germont, Rouen, 76031, France. guillaume.feugray@chu-rouen.fr.
  • Dumesnil C; Department of Internal Medicine, CHU Rouen, Rouen, F-76000, France.
  • Brunel V; Department of Pediatric Onco-Hematology, CHU Rouen, Rouen, F-76000, France.
  • Benhamou Y; Department of General Biochemistry, CHU Rouen, Rouen, F-76000, France.
  • Quillard Muraine M; Department of Internal Medicine, Normandie Univ, UNIROUEN, INSERM U1096, CHU Rouen, Rouen, F-76000, France.
  • Billoir P; Department of General Biochemistry, Normandie Univ, UNIROUEN, INSERM U1404 INSERMU1073 ADEN, CHU Rouen, CIC-CRB, Rouen, F-76000, France.
Lipids Health Dis ; 23(1): 140, 2024 May 16.
Article en En | MEDLINE | ID: mdl-38755670
ABSTRACT
Sickle cell disease (SCD) is a lifelong blood disorder affecting approximately 100,000 people in the United States and is one of the most common monogenic diseases. A serious complication of SCD is acute chest syndrome (ACS). ACS is a condition with a high rate of morbidity and mortality. The aim of the study was to assess hemolysis and lipid parameters in a cohort of confirmed SCD patients to predict ACS development in the following year.Standard lipid were performed (triglycerides, total cholesterol, high-density cholesterol, low-density cholesterol) panel to calculate of non-HDL-C, large buoyant LDL cholesterol (lbLDL-C) and small dense LDL cholesterol (sdLDL-C) with Sampson equation. Hemolysis and hematologic parameters were also evaluated.Among 91 patients included between September 2018 and June 2021, thirty-seven patients had history of ACS and 6 patients developed ACS during following year. In unadjusted logistic regression, total bilirubin was associated with ACS occurrence (RR 1.2 [1.05-1.51] p = 0.013). Concerning lipid profile, non-HDL-C (RR 0.87 [0.0.67-0.99] p = 0.04) and sdLDL-C (RR 0.78 [0.49-0.96] p = 0.03) were associated with ACS occurrence decrease. C-reactive protein was associated with ACS occurrence (RR 1.27 [1.065-1.85] p = 0.011).Based on these findings, this study demonstrated that several biomarker easily available can be used at steady state to predict ACS in the following year. The validation of these results are required to ensure the reproducibility of the findings.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Síndrome Torácico Agudo / Hemólisis / Anemia de Células Falciformes Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Lipids Health Dis Asunto de la revista: BIOQUIMICA / METABOLISMO Año: 2024 Tipo del documento: Article País de afiliación: Francia

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Síndrome Torácico Agudo / Hemólisis / Anemia de Células Falciformes Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Lipids Health Dis Asunto de la revista: BIOQUIMICA / METABOLISMO Año: 2024 Tipo del documento: Article País de afiliación: Francia