Human recombinant granulocyte-macrophage colony-stimulating factor: a multilineage hematopoietin.
Science
; 230(4730): 1171-3, 1985 Dec 06.
Article
en En
| MEDLINE
| ID: mdl-3877981
ABSTRACT
Human recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF) was tested for its ability to induce colony formation in human bone marrow that had been enriched for progenitor cells. In addition to its expected granulocyte-monocyte colony-stimulating activity, the recombinant GM-CSF had burst-promoting activity for erythroid burst-forming units and also stimulated colonies derived from multipotent (mixed) progenitors. In contrast, recombinant erythroid-potentiating activity did not stimulate erythroid progenitors. The experiments prove that human GM-CSF has multilineage colony-stimulating activity.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Médula Ósea
/
Proteínas Recombinantes
/
Factores Estimulantes de Colonias
/
Granulocitos
/
Macrófagos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Science
Año:
1985
Tipo del documento:
Article