GI.1 Norovirus Neutralizing Antibody Levels Are Correlated with GI.1 Histo-blood Group Antigen-Blocking Antibody Levels.
J Infect Dis
; 2024 Jun 12.
Article
en En
| MEDLINE
| ID: mdl-38864524
ABSTRACT
BACKGROUND:
The in vitro cultivation of human noroviruses allows a comparison of antibody levels measured in neutralization and histoblood group antigen (HBGA)-blocking assays.METHODS:
Serum samples collected during the evaluation of an investigational norovirus vaccine (HIL-214 [formerly TAK-214]) were assayed for neutralizing antibody levels against the vaccine's prototype Norwalk virus/GI.1 (P1) virus strain. Results were compared to those previously determined using HBGA-blocking assays.RESULTS:
Neutralizing antibody seroresponses were observed in 83% of 24 vaccinated adults, and antibody levels were highly correlated (r=0.81, P<0.001) with those measured by HBGA-blocking.CONCLUSIONS:
GI.1-specific HBGA-blocking antibodies are a surrogate for neutralization of GI.1 norovirus.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
J Infect Dis
/
J. infect. dis
/
Journal of infectious diseases
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos