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Fusobacterium Detected in Barrett's Esophagus and Esophageal Adenocarcinoma Tissues.
Tahara, Tomomitsu; Shijimaya, Takuya; Yamazaki, Jumpei; Kobayashi, Sanshiro; Horitani, Anna; Matsumoto, Yasushi; Nakamura, Naohiro; Okazaki, Takashi; Takahashi, Yu; Tomiyama, Takashi; Honzawa, Yusuke; Fukata, Norimasa; Fukui, Toshiro; Naganuma, Makoto.
Afiliación
  • Tahara T; Third department of Internal Medicine, Kansai Medical University, Hirakata, Japan.
  • Shijimaya T; Third department of Internal Medicine, Kansai Medical University, Hirakata, Japan.
  • Yamazaki J; Translational Research Unit, Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
  • Kobayashi S; One Health Research Center, Hokkaido University, Sapporo, Japan.
  • Horitani A; Third department of Internal Medicine, Kansai Medical University, Hirakata, Japan.
  • Matsumoto Y; Third department of Internal Medicine, Kansai Medical University, Hirakata, Japan.
  • Nakamura N; Third department of Internal Medicine, Kansai Medical University, Hirakata, Japan.
  • Okazaki T; Third department of Internal Medicine, Kansai Medical University, Hirakata, Japan.
  • Takahashi Y; Third department of Internal Medicine, Kansai Medical University, Hirakata, Japan.
  • Tomiyama T; Third department of Internal Medicine, Kansai Medical University, Hirakata, Japan.
  • Honzawa Y; Third department of Internal Medicine, Kansai Medical University, Hirakata, Japan.
  • Fukata N; Third department of Internal Medicine, Kansai Medical University, Hirakata, Japan.
  • Fukui T; Third department of Internal Medicine, Kansai Medical University, Hirakata, Japan.
  • Naganuma M; Third department of Internal Medicine, Kansai Medical University, Hirakata, Japan.
Cancer Invest ; 42(6): 469-477, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38913915
ABSTRACT
We examined Fusobacterium nucreatum (F. nucleatum) and whole Fusobacterium species (Pan-fusobacterium) in non-neoplastic Barrett's esophagus (BE) from patients without cancer (n = 67; N group), with esophageal adenocarcinoma (EAC) (n = 27) and EAC tissue (n = 22). F. nucleatum was only detectable in 22.7% of EAC tissue. Pan-fusobacterium was enriched in EAC tissue and associated with aggressive clinicopathological features. Amount of Pan-fusobacterium in non-neoplastic BE was correlated with presence of hital hernia and telomere shortening. The result suggested potential association of Fusobacterium species in EAC and BE, featuring clinicpathological and molecular features.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Esófago de Barrett / Neoplasias Esofágicas / Adenocarcinoma Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Invest Año: 2024 Tipo del documento: Article País de afiliación: Japón
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Esófago de Barrett / Neoplasias Esofágicas / Adenocarcinoma Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Invest Año: 2024 Tipo del documento: Article País de afiliación: Japón