HNF1É promotes colorectal cancer progression via HKDC1-mediated activation of AKT/AMPK signaling pathway.
Gene
; 928: 148752, 2024 Nov 30.
Article
en En
| MEDLINE
| ID: mdl-38986750
ABSTRACT
The hepatocyte nuclear factor-1 (HNF1É) is a transcription factor that contributes to several kinds of cancer progression. However, very little is known regarding the mechanisms underlying the activity of HNF1É. We aimed to explore the role of HNF1É in the progress of colorectal cancer (CRC) and elucidate its molecular mechanism. HNF1É expression was upregulated in CRC samples and high expression of HNF1É was associated with poor prognosis of CRC patients. HNF1α knockdown and overexpression inhibited and promoted proliferation, migration and invasion of CRC cells both in vitro and in vivo respectively. Mechanistically, HNF1É increased the transcriptional activity of hexokinase domain component 1ï¼HKDC1ï¼promoter, thus activated AKT/AMPK signaling. Meanwhile, HKDC1 upregulation was important for the proliferation, migration and invasion of CRC cells and knockdown of HKDC1 significantly reversed the proliferation, migration and invasion induced by HNF1α overexpression. Taken together, HNF1É contributes to CRC progression and metastasis through binding to HKDC1 and activating AKT/AMPK signaling. Targeting HNF1É could be a potential therapeutic strategy for CRC patients.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Colorrectales
/
Transducción de Señal
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Regulación Neoplásica de la Expresión Génica
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Movimiento Celular
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Progresión de la Enfermedad
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Proliferación Celular
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Proteínas Proto-Oncogénicas c-akt
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Factor Nuclear 1-alfa del Hepatocito
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Proteínas Quinasas Activadas por AMP
Límite:
Animals
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Female
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Humans
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Male
Idioma:
En
Revista:
Gene
Año:
2024
Tipo del documento:
Article
País de afiliación:
China