Cervical cancer risk in association with TNF-alpha gene polymorphisms in Bangladeshi women.
Tumour Biol
; 46(1): 13-24, 2024.
Article
en En
| MEDLINE
| ID: mdl-39031417
ABSTRACT
BACKGROUND:
Tumor necrosis factor-alpha (TNF-α) is among the vital pro-inflammatory cytokines that potentially exerts a significant influence on the immune response, hence potentially regulating the advancement of cervical lesions.OBJECTIVE:
Our study objective was to examine the relationship between two single nucleotide polymorphisms (SNPs) (rs1799724 and rs1800629) of TNF-α and the risk of cervical cancer in women from Bangladesh.METHODS:
We recruited 133 patients with cervical cancer and 126 healthy individuals for this study. Genotyping was performed using real-time PCR SNP genotyping assay. Multivariate logistic regression analysis was used to determine the odds ratio (OR) along with 95% confidence intervals (CI) and p-values.RESULTS:
For rs1799724 (Câ>âT) polymorphism, TT mutant homozygous genotype carried 3.26 times increased risk of developing cervical cancer (ORâ=â3.26, 95% CIâ=â1.15-9.28, pâ=â0.027). Polymorphism of rs1800629 (Gâ>âA) was also related to an elevated risk of cervical cancer. Individuals with the AG heterozygous genotype (ORâ=â2.85, 95% CIâ=â1.20-6.74, pâ=â0.017) and AA mutant homozygous genotype (ORâ=â4.55, 95% CIâ=â1.24-16.60, pâ=â0.022) also had a higher likelihood of having cervical cancer. Moreover, we found that injectable contraceptives increase the risk of cervical cancer. Individuals who smoked and/or had first-degree relatives with cancer were more likely to carry the risk allele, which increases the likelihood of developing cervical cancer.CONCLUSION:
TNF-α polymorphisms in rs1799724 and rs1800629 increase the susceptibility of developing cervical cancer in women from Bangladesh.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias del Cuello Uterino
/
Factor de Necrosis Tumoral alfa
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Predisposición Genética a la Enfermedad
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Polimorfismo de Nucleótido Simple
/
Genotipo
Límite:
Adult
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Female
/
Humans
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Middle aged
País/Región como asunto:
Asia
Idioma:
En
Revista:
Tumour Biol
Asunto de la revista:
NEOPLASIAS
Año:
2024
Tipo del documento:
Article
País de afiliación:
Bangladesh