Surgery alone versus surgery plus adjuvant radiotherapy for WHO grade 2 meningioma: meta-analysis of reconstructed time-to-event data.
Neurosurg Rev
; 47(1): 702, 2024 Sep 28.
Article
en En
| MEDLINE
| ID: mdl-39333271
ABSTRACT
INTRODUCTION:
WHO Grade 2 meningiomas present diagnostic and management challenges. Surgery, particularly gross total resection (GTR), is crucial, often followed by adjuvant radiotherapy (RT); however, there are clinical equipoise and ongoing randomized trials of RT after GTR.METHODS:
This systematic review evaluates the efficacy of gross total resection (GTR) and GTR plus adjuvant radiotherapy (RT) for WHO grade 2 meningiomas, adhering to PRISMA guidelines. It excludes irrelevant studies, conducts a thorough search until January 2024, and specifically analyzes overall survival (OS) and progression-free survival (PFS) outcomes for WHO grade 2 meningiomas. Statistical analysis adopts a two-stage approach with the R package "IPDfromKM," and quality assessment is conducted using the ROBINS-I tool.RESULTS:
In our analysis of 23 studies involving 3822 WHO grade 2 meningioma patients, GTR + RT resulted in a significantly longer PFS (HR 0.849, 95% CI 0.730 to 0.988, p = 0.035) compared to GTR alone. Although OS trended better with GTR + RT (HR 0.79, 95% CI 0.57 to 1.11, p = 0.173), the difference was not statistically significant, suggesting the need for further investigation.CONCLUSION:
Our study reveals a benefit to adjuvant RT for improving PFS for WHO grade 2 meningiomas. Integrating molecular characteristics into treatment strategies will refine the management of these tumors in the future.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Meníngeas
/
Meningioma
Límite:
Humans
Idioma:
En
Revista:
Neurosurg Rev
Año:
2024
Tipo del documento:
Article
País de afiliación:
Brasil