Disease accompanying in utero viral infection. The role of maternal antibody in tissue injury after transplacental infection with lymphocytic choriomeningitis virus.
J Exp Med
; 135(4): 827-38, 1972 Apr 01.
Article
en En
| MEDLINE
| ID: mdl-4259667
ABSTRACT
Early, after in utero infection with LCM virus, SWR/J and HA/ICR mice developed manifestations of immune complex disease. Observations based on nursing such mice with virus-infected, immune, or noninfected mouse mothers indicated that maternal antiviral antibody was responsible for the early immune complex glomerulonephritis. Despite comparable viral persistance, in utero-infected offspring failed to develop glomerulonephritis when nursed by noninfected mouse mothers, but did when suckled by virus-infected mouse mothers. Nursing by mouse mothers carrying high titers of anti-LCM viral antibody markedly enhanced the Ig glomerular deposits and the resultant nephritis.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Complicaciones Infecciosas del Embarazo
/
Inmunoglobulinas
/
Enfermedades Fetales
/
Coriomeningitis Linfocítica
/
Intercambio Materno-Fetal
Límite:
Animals
/
Pregnancy
Idioma:
En
Revista:
J Exp Med
Año:
1972
Tipo del documento:
Article