Double-blind comparison of amoxapine and imipramine in the treatment of depressed patients.
J Clin Psychiatry
; 45(2): 54-56, 57-9, 1984 Feb.
Article
en En
| MEDLINE
| ID: mdl-6363397
ABSTRACT
A 5-week double-blind study compared amoxapine to imipramine (21 dosage ratio) in the treatment of depressed outpatients. The two agents were similar in anti-depressant efficacy and rapidity of action. The most common adverse reactions to both drugs were anticholinergic effects and sedation; cardiovascular effects were minimal. A few amoxapine-treated patients developed adverse effects typical of neuroleptic drugs some experienced extrapyramidal signs, one developed galactorrhea, and most showed elevated plasma prolactin concentrations. Amoxapine was associated with significant neuroleptic activity in plasma. No correlation was found between blood levels of either drug and therapeutic response.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Trastorno Depresivo
/
Dibenzoxazepinas
/
Amoxapina
/
Imipramina
Tipo de estudio:
Clinical_trials
Límite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
/
Pregnancy
Idioma:
En
Revista:
J Clin Psychiatry
Año:
1984
Tipo del documento:
Article