Immunosuppressive activity of rhesus monkey pregnancy serum.
Am J Obstet Gynecol
; 139(8): 932-6, 1981 Apr 15.
Article
en En
| MEDLINE
| ID: mdl-6452817
ABSTRACT
Normal pregnancy serum from the rhesus monkey was found to have immunosuppressive activity. Using two-way stimulation, the mixed lymphocyte response was suppressed as much as 80%. Control serum from nonpregnant females was not suppressive. The inhibiting factor was found to have the following characteristics (1) it was nonspecific in activity; (2) it inhibited the mixed lymphocyte response 20% at in vitro concentrations of 1%; (3) it was heat stable (56 degrees C for 30 minutes) and nondialyzable; (4) it was present in both the IgM- and IgG-containing fractions of pregnancy serum; (5) it was detected in postpartum and second and third trimester serum; and (6) it was at low levels or absent from the serum of two pregnancies which terminated in unexplained stillbirths.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Preñez
/
Inmunosupresores
Límite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Am J Obstet Gynecol
Año:
1981
Tipo del documento:
Article