Alternate organization of alpha G-Philadelphia globin genes among U.S. black and Italian Caucasian heterozygotes.
Hemoglobin
; 8(6): 537-47, 1984.
Article
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| MEDLINE
| ID: mdl-6526651
ABSTRACT
Seven Hb G-Philadelphia (Hb G) heterozygotes from three Caucasian families from Northern Italy and Sardegna were found to have proportions of Hb G averaging 23%. This value is considerably lower than the 34% or 48% found in Blacks from the Southeastern U.S.A. in whom the alpha G gene is in linkage with alpha-thalassemia-2, i.e. the alpha o alpha G/alpha alpha or alpha o alpha G/alpha o alpha genotypes. Gene mapping identified tandem organization of the alpha G gene in cis with a normal alpha A gene, i.e. the alpha alpha G/alpha alpha genotype, among the Hb G heterozygotes from Italy. The data on the Italian heterozygotes are similar to those obtained by Bruzdzinski et al (14) on a Black family. These results indicate alternate organization of the alpha G genes probably across racial or ethnic boundaries. Comparison of the mean cellular globin amount of alpha G/alpha G gene/cell among Hb G heterozygotes with 4, 3, 2 or 1 alpha globin genes (i.e. alpha A + alpha G) revealed considerable reactivation of individual alpha genes in conditions of mild to severe alpha globin deficiencies.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Hemoglobinas Anormales
/
Población Negra
/
Población Blanca
/
Heterocigoto
Límite:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
País/Región como asunto:
America do norte
/
Europa
Idioma:
En
Revista:
Hemoglobin
Año:
1984
Tipo del documento:
Article