DNA sequence of the gene encoding the E alpha Ia polypeptide of the BALB/c mouse.
Science
; 218(4578): 1229-32, 1982 Dec 17.
Article
en En
| MEDLINE
| ID: mdl-6815800
ABSTRACT
A 3.4-kilobase DNA fragment containing the gene coding for the E alpha chain of an Ia (I region-associated) antigen from the BALB/c mouse has been sequenced. It contains at least three exons, which correlate with the major structural domains of the E alpha chain-the two external domains alpha 1 and alpha 2, and the transmembrane-cytoplasmic domain. The coding sequence of the mouse E alpha gene shows striking homology to its counterpart at the DNA and protein levels. The translated alpha 2 exon demonstrates significant similarity to beta 2-microglobulin, to immunoglobulin constant region domains, and to certain domains of transplantation antigens. These observations and those of others suggest that the Ia antigen, transplantation antigen, and immunoglobulin gene families share a common ancestor.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Genes MHC Clase II
/
Ratones Endogámicos BALB C
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
1982
Tipo del documento:
Article