Nonimmunological production of leukotrienes induced by platelet-activating factor.
Science
; 218(4569): 286-9, 1982 Oct 15.
Article
en En
| MEDLINE
| ID: mdl-7123233
ABSTRACT
Platelet-activating factor caused rapid pulmonary vasoconstriction and edema in isolated lungs perfused with albumin-free salt solution devoid of formed blood elements. These effects may be due in part to the action of leukotrienes D4 and C4, which were identified by bioassay and high-pressure liquid chromatography in the lung effluent after stimulation by platelet-activating factor. These findings help illuminate some of the deleterious effects that platelet-activating factor elicits in anaphylactic reactions and possibly in other forms of lung injury.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Factor de Activación Plaquetaria
/
SRS-A
/
Pulmón
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
1982
Tipo del documento:
Article