[The effect of staphylococcal peptidoglycan on macrophage interferon formation and bactericidal activity]. / Vliianie stafilokokkovogo peptidoglikana na interferonoobrazovanie i bakteritsidnuiu aktivnost' makrofagov.

ABSTRACT

Staphylococcus aureus cell-wall peptidoglycan has been shown to stimulate the bactericidal activity of peritoneal exudate macrophages. A more pronounced activating effect of peptidoglycan on the bactericidal activity of macrophages has been detected in the stimulated test. Peptidoglycan in doses of 5-100 mg induced interferon production by intact mouse splenocytes after 24-hour exposition with it. Peptidoglycan has been found to produce the most intensive effect on interferon production when injected intraperitoneally in a dose of 100 mg after 4-hour exposition.