Focal segmental glomerular sclerosis, a type of intractable chronic glomerulonephritis, is a stem cell disorder.
J Exp Med
; 179(3): 1053-8, 1994 Mar 01.
Article
en En
| MEDLINE
| ID: mdl-7906704
ABSTRACT
The etiopathogenesis of focal and segmental glomerular sclerosis (FGS) remains unknown. Using a new animal model for FGS (FGS mouse), we demonstrate here that bone marrow transplantation from normal mice to FGS mice with a high grade of proteinuria (+ + +) ameliorates FGS, and that the transplantation of bone marrow cells or purified hemopoietic stem cells (HSCs) from FGS mice induces FGS in normal mice. These findings strongly suggest that FGS is a stem cell disorder; the abnormalities may be genetically programmed at the level of HSCs.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Células Madre Hematopoyéticas
/
Glomeruloesclerosis Focal y Segmentaria
/
Trasplante de Médula Ósea
/
Trasplante de Células Madre Hematopoyéticas
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
J Exp Med
Año:
1994
Tipo del documento:
Article
País de afiliación:
Japón