Long-term production and delivery of human growth hormone in vivo.
Proc Natl Acad Sci U S A
; 91(23): 10967-71, 1994 Nov 08.
Article
en En
| MEDLINE
| ID: mdl-7971993
ABSTRACT
The application of somatic cell gene therapy to large patient populations will require the development of safe and practical approaches to the generation and characterization of genetically manipulated cells. Transkaryotic implantation is a gene therapy system based on the production of clonal strains of engineered primary and secondary cells, using non-viral methods. We demonstrate here that, on implantation, these clonal cell strains stably and reproducibly deliver pharmacologic quantities of protein for the lifetime of the experimental animals.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Hormona del Crecimiento
Límite:
Animals
Idioma:
En
Revista:
Proc Natl Acad Sci U S A
Año:
1994
Tipo del documento:
Article