Beta-adrenergic receptor kinase-2 and beta-arrestin-2 as mediators of odorant-induced desensitization.
Science
; 259(5096): 825-9, 1993 Feb 05.
Article
en En
| MEDLINE
| ID: mdl-8381559
ABSTRACT
beta-Adrenergic receptor kinase (beta ARK) and beta-arrestin function in the homologous or agonist-activated desensitization of G protein-coupled receptors. The isoforms beta ARK-2 and beta-arrestin-2 are highly enriched in and localized to the dendritic knobs and cilia of the olfactory receptor neurons where the initial events of olfactory signal transduction occur. Odorants induce a rapid and transient elevation of adenosine 3',5'-monophosphate (cAMP), which activates a nonspecific cation channel and produces membrane depolarization. Preincubation of rat olfactory cilia with antibodies raised against beta ARK-2 and beta-arrestin-2 increased the odorant-induced elevation of cAMP and attenuated desensitization. These results suggest that beta ARK-2 and beta-arrestin-2 mediate agonist-dependent desensitization in olfaction.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Bulbo Olfatorio
/
Proteínas Quinasas
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Olfato
/
Cornetes Nasales
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Receptores Adrenérgicos beta
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Proteínas Quinasas Dependientes de AMP Cíclico
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Proteínas de Unión al GTP
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Arrestinas
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Proteínas del Ojo
/
Mecanorreceptores
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
1993
Tipo del documento:
Article