Characterization of a transcriptional attenuator within the 5' R region of the human T cell leukemia virus type 1.
AIDS Res Hum Retroviruses
; 11(9): 1123-9, 1995 Sep.
Article
en En
| MEDLINE
| ID: mdl-8554910
ABSTRACT
Several regulatory sequences have been characterized in the HTLV-I promoter. We report here identification of a sequence element downstream of the transcriptional start site within the first 52 nucleotides of the 5' R region, which acts negatively on the activity of the HTLV-I promoter. Determination of the half-lives of the RNAs either including or lacking this sequence element showed that the observed effect intervenes at the transcriptional level. This negative element does not affect basal activity of the HTLV-I TATA box, but down-regulates transcription induced by strong activators. Thus, we propose that this so-called negative regulatory sequence functions as an attenuator of transcription.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Virus Linfotrópico T Tipo 1 Humano
/
Genes Virales
Límite:
Humans
Idioma:
En
Revista:
AIDS Res Hum Retroviruses
Asunto de la revista:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Año:
1995
Tipo del documento:
Article
País de afiliación:
Francia