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Automation of toxicological screenings on a Hewlett Packard Chemstation GC-MS system.
Fiers, T; Maes, V; Sevens, C.
Afiliación
  • Fiers T; Department of Clinical Chemistry, Academisch Ziekenhuis Vrije Universiteit Brussel, Belgium.
Clin Biochem ; 29(4): 357-61, 1996 Aug.
Article en En | MEDLINE | ID: mdl-8828966
OBJECTIVES: To optimize the interpretation of GC-MS toxicological screenings (i.e., to facilitate ion specific queries, create custom reports specifically adapted to each confirmation procedure, and eliminate redundant and/or inaccurate data on library search reports). DESIGN AND METHODS: The MS Chemstation software of the Hewlett Packard 5972 is constructed in a modular way. We made extensive modifications to two modules, the data analysis and the report modules, using the built-in MS Chemstation macro language. RESULTS: Ion specific queries were automated for over 60 commonly encountered analytes. Custom reports were created for the confirmation of positive drugs-of-abuse immunoassay results. With the incorporation of decision support rules into the data processing and the reporting phases, we obtained sensitive, accurate, and concise reports. CONCLUSIONS: The MS Chemstation software can be tailored to the needs of each individual application. The incorporation of a rule-based decision support system enhances the quality of the GC-MS toxicological screenings and results in faster, easier, and more reliable processing.
Asunto(s)
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Toxicología / Cromatografía de Gases y Espectrometría de Masas Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Clin Biochem Año: 1996 Tipo del documento: Article País de afiliación: Bélgica
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Toxicología / Cromatografía de Gases y Espectrometría de Masas Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Clin Biochem Año: 1996 Tipo del documento: Article País de afiliación: Bélgica