Structural conservation in prokaryotic and eukaryotic potassium channels.
Science
; 280(5360): 106-9, 1998 Apr 03.
Article
en En
| MEDLINE
| ID: mdl-9525854
ABSTRACT
Toxins from scorpion venom interact with potassium channels. Resin-attached, mutant K+ channels from Streptomyces lividans were used to screen venom from Leiurus quinquestriatus hebraeus, and the toxins that interacted with the channel were rapidly identified by mass spectrometry. One of the toxins, agitoxin2, was further studied by mutagenesis and radioligand binding. The results show that a prokaryotic K+ channel has the same pore structure as eukaryotic K+ channels. This structural conservation, through application of techniques presented here, offers a new approach for K+ channel pharmacology.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Conformación Proteica
/
Venenos de Escorpión
/
Proteínas Bacterianas
/
Canales de Potasio
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Science
Año:
1998
Tipo del documento:
Article
País de afiliación:
Estados Unidos