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Antihyperglycemic activities of cryptolepine analogues: an ethnobotanical lead structure isolated from Cryptolepis sanguinolenta.
Bierer, D E; Dubenko, L G; Zhang, P; Lu, Q; Imbach, P A; Garofalo, A W; Phuan, P W; Fort, D M; Litvak, J; Gerber, R E; Sloan, B; Luo, J; Cooper, R; Reaven, G M.
Afiliación
  • Bierer DE; Shaman Pharmaceuticals, Inc., 213 East Grand Avenue, South San Francisco, California 94080, USA. dbierer@shaman.com
J Med Chem ; 41(15): 2754-64, 1998 Jul 16.
Article en En | MEDLINE | ID: mdl-9667966
Cryptolepine (1) is a rare example of a natural product whose synthesis was reported prior to its isolation from nature. In the previous paper we reported the discovery of cryptolepine's antihyperglycemic properties. As part of a medicinal chemistry program designed to optimize natural product lead structures originating from our ethnobotanical and ethnomedical field research, a series of substituted and heterosubstituted cryptolepine analogues was synthesized. Antihyperglycemic activity was measured in vitro and in an NIDDM mouse model to generate the first structure-bioactivity study about the cryptolepine nucleus.
Asunto(s)
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Plantas Medicinales / Quinolinas / Alcaloides / Hipoglucemiantes / Indoles Límite: Animals Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 1998 Tipo del documento: Article País de afiliación: Estados Unidos
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Plantas Medicinales / Quinolinas / Alcaloides / Hipoglucemiantes / Indoles Límite: Animals Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 1998 Tipo del documento: Article País de afiliación: Estados Unidos