Constant region of a kappa III immunoglobulin light chain as a major AL-amyloid protein.
Scand J Immunol
; 48(1): 92-8, 1998 Jul.
Article
en En
| MEDLINE
| ID: mdl-9714416
ABSTRACT
AL-amyloidoses are generally described as a group of disorders in which N-terminal fragments of monoclonal immunoglobulin light chains are transferred into amyloid fibrils. We have, by amino acid sequence analyses and immunological methods, characterized the Bence-Jones protein and the corresponding AL protein as a kappa III immunoglobulin light chain from material of a patient with systemic AL-amyloidosis presenting as a local inguinal tumour. The two proteins showed some unique features. The major part of the AL amyloid fibril protein consisted of C-terminal fragments of the Bence-Jones protein. Furthermore, both the Bence-Jones protein and the AL protein were glycosylated, with possibly a glycosylation in the constant part of the light chain.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Proteína de Bence Jones
/
Regiones Constantes de Inmunoglobulina
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Cadenas kappa de Inmunoglobulina
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Amiloide
Límite:
Aged
/
Female
/
Humans
Idioma:
En
Revista:
Scand J Immunol
Año:
1998
Tipo del documento:
Article
País de afiliación:
Noruega